Traditionally clinical trial outcomes are recorded as single reports (often with handcrafted
Narrative descriptions) at face-to-face research clinic visits. Typically, original medical records are gathered, copied and couriered to a trial coordinating centre, and then verified by trial clinicians according to pre-specified rules. The process is inefficient, expensive, and prone to errors.
We are looking back into previous trial datasets linked to other routinely collected medical data, acquired during people’s usual care, to identify more streamlined, and potentially more reliable methods to cost-effectively collect information for trials with fewer steps, with a particular focus on vascular outcomes and bleeding outcomes.
We are also developing methods to rapidly ascertain outcomes relevant to Covid-19 trials using the RECOVERY trial platform, which has recruited and started following about 40,000 participants in the UK since the beginning of the Covid-19 pandemic: https://www.recoverytrial.net/
£650m for UK’s life sciences sector may contribute to improved clinical trials
26 May 2023
HDR UK welcomes the Chancellor of the Exchequer’s pledge of £650 million for the UK’s life sciences including £121 million to improve clinical trials to bring new medicines to patients faster.
EMPA-KIDNEY trial: Effect of empagliflozin on chronic kidney disease progression
7 December 2022
EMPA-KIDNEY is an international clinical trial by Oxford Population Health scientists in collaboration with academics spanning eight countries. The study recruited over 6000 participants to...