Andrea Rodriguez-Martinez, Rafael Ayala, Joram M. Posma, Nikita Harvey, Beatriz Jiménez, Kazuhiro Sonomura, Taka-Aki Sato, Fumihiko Matsuda, Pierre Zalloua, Dominique Gauguier, Jeremy K. Nicholson and Marc-Emmanuel Dumas
Motivation Data processing is a key bottleneck for 1H NMR-based metabolic profiling of complex biological mixtures, such as biofluids. These spectra typically contain several thousands of signals, corresponding to possibly few hundreds of metabolites. A number of binning-based methods have been proposed to reduce the dimensionality of 1 D 1H NMR datasets, including statistical recoupling of variables (SRV). Here, we introduce a new binning method, named JBA (“pJRES Binning Algorithm”), which aims to extend the applicability of SRV to pJRES spectra.
Mapping multimorbidity in individuals with schizophrenia and bipolar disorders: evidence from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register
21 April 2022
People with severe mental illness, such as schizophrenia spectrum disorders or bipolar disorders, have higher death rates. It is difficult to study mental health records at scale, so a team of...
Evaluation of the ASSIGN open-source deterministic address-matching algorithm for allocating unique property reference numbers to general practitioner-recorded patient addresses
20 April 2022
Being able to link addresses across systems offers a valuable resource for health data science. However, they are often not standardised despite a government push towards this. Researchers at the...
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
18 January 2022
Overview Alzheimer’s disease (AD) is a highly prevalent form of dementia – the genetic variations underlying the disease are poorly understood and the number and effectiveness of drug...